| Registro completo |
| Provedor de dados: |
Biocell
|
| País: |
Argentina
|
| Título: |
A likely role for a novel PH-domain containing protein, PEPP2, in connecting membrane and cytoskeleton
|
| Autores: |
Zou,Yi
Zhong,Wenping
|
| Data: |
2012-12-01
|
| Ano: |
2012
|
| Palavras-chave: |
Microtubule
Membrane
Phosphoinositide
Microviscosity
Wortmannin
|
| Resumo: |
PH domains (pleckstrin homology) are well known to bind membrane phosphoinositides with different specificities and direct PH domain-containing proteins to discrete subcellular apartments with assistances of alternative binding partners. PH domain-containing proteins are found to be involved in a wide range of cellular events, including signalling, cytoskeleton rearrangement and vesicular trafficking. Here we showed that a novel PH domain-containing protein, PEPP2, displayed moderate phosphoinositide binding specificity. Full length PEPP2 associated with both plasma membrane and microtubules. The membrane-associated PEPP2 nucleated at cell-cell contacts and the leading edge of migrating cells. Overexpression of PEPP2 increased membrane microviscosity, indicating a potential role of PEPP2 in regulating function of membrane and microtubules.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452012000300005
|
| Editor: |
Sociedad Latinoamericana de Microscopía Electrónica.; Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina)
|
| Formato: |
text/html
|
| Fonte: |
Biocell v.36 n.3 2012
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
|
